Understanding resistance. Advancing discovery.
When Cancer Stops Responding, Our Questions Don’t.
HER2T Laboratories is building a scientific intelligence to investigate why HER2-positive cancers develop treatment resistance — and to explore the biological vulnerabilities that could lead to new, more effective therapies.
HER2T Mind
Investigate. Understand. Discover.
Answers draw on the platform’s existing papers, questions and beliefs, with citations and honest confidence. Research information only — not medical advice.
Cancers can adapt and become resistant to treatments that once worked.
Investigate why this happens and identify new, scientifically testable strategies.
- Connect scientific evidence
- Analyze biological mechanisms
- Generate and test hypotheses
- Advance research toward better outcomes
Transparent science. Real progress.
Every number below is a live count of the actual work done so far — nothing invented, nothing projected.
Understand My Cancer
PlannedA future private workspace to organize your records, explore your treatment history and discover relevant research. It is not built yet and holds no personal data.
Available now: the plain-English HER2 guide
Explore the Research
Enter the HER2T Research Lab to investigate evidence, resistance mechanisms and open scientific questions.
See the open questionsPreview the workspacesPrototype
A clickable preview of both workspaces with fictional people and a scripted Mind. Nothing is saved. Sign in or use a demo login to open them.
Scientific Evidence Intelligence
A structured approach to gather, evaluate and connect research.
Treatment Resistance Investigation
Focused on why HER2-positive cancers stop responding to therapies.
Computational Research
Molecular simulations of HER2 mechanisms. Compute is currently paused.
Personalized Understanding
Helping patients make sense of their own cancer journey.
Scientific Validation
Committed to transparency, reproducibility and expert review.
A focused research mission
Turning Questions Into Discoveries
We are developing HER2T Mind — an evolving scientific intelligence designed to examine evidence, identify knowledge gaps, investigate hypotheses, and help advance research toward better outcomes for people with HER2-positive cancers. We have not discovered a cure; we are building the tools to investigate rigorously.
Learn more about our missionThe central question
Why Do HER2-Positive Cancers Become Resistant?
Exploring the biological mechanisms, signaling pathways and molecular changes that allow cancer cells to adapt — and identifying potential vulnerabilities.
Real HER2 structure · PDB 1N8Z
How HER2T works
From Evidence to Impact
The cycle of investigation we follow. Showing the method is not a claim that every step has been completed — no finding has been independently validated yet.
- 1. Gather evidence
- 2. Identify gaps
- 3. Develop hypotheses
- 4. Investigate & analyze
- 5. Validate findings
- 6. New questions
Explore the Research Platform
Tools for investigating HER2 biology, treatment resistance and new possibilities.
The Mind
See what the platform believes, and how sure it is.
Discovery Console
Research questions, hypotheses and findings.
Knowledge Map
Connections across research, evidence and mechanisms.
Living HER2 Model
HER2 structure, interactions and biology.
Research Agenda
Open questions and current investigations.
Where we are right now
UNDERSTAND · SIMULATE · DISCOVER
See exactly where we are and where we’re headed — a live progress bar with the milestones we’ve built and the ones ahead. This is a journey you can take with us, not a roadmap hidden away. Nothing is marked done unless you can check it yourself.
Support this research — help carry HER2T from understanding to real simulation and discovery.
What’s ready to act on
Live countsReady for Expert Review
Lead dossiers to grade, plus questions the platform needs a human to scope.
See what’s readyReady for Compute Lab
Findings worth a real simulation. Compute is paused under a safety freeze, so no simulations are running and none are being sent to a GPU node.
See what’s readyReady for Wet Lab
Questions that will need a physical experiment to settle.
See what’s readyThe Living HER2 Map
HER2 drawn as its real regions — each one filling in with everything the platform has learned. Bright means grounded knowledge; dim and dark means our understanding runs out. The dark is the point.
Find a previously unknown weakness in HER2-driven cancer — and design the decisive experiment that could test it.
The twin comes first. Every tool here — the model contests, the collision detector, the curiosity engine, the living HER2 map, the computational verifier — exists to deepen the twin’s understanding of HER2 and move one honest question up a ladder: from something nobody had framed, to a real measurement that changes what we know. That ladder is below, with the real counts right now.
Where honesty draws the line: HER2T can carry a question all the way to the decisive experiment — the single test that would settle it — and can arrange for that test to be run by a qualified laboratory or research partner. But HER2T cannot declare a physical result itself, and it never dresses up a prediction as a measurement. The last rungs, Measured and Model updated, only light up when a real experiment produces a documented, cited result. That boundary is the point: computation can propose the experiment worth running, but only reality can settle it.
See what the platform believes — and how sure it is
A living field of every claim it holds. Size is how much a claim matters, colour is what it currently believes, brightness is how sure it is. It sits perfectly still until real evidence moves it — then you watch the belief flare or fracture. Nothing here is on a timer; every motion is caused.
Enter the MindWhat it has learned recently
Round complete. Leading on held-out evidence: Kinetic state graph (held-out 100). 0 missing-variable hypothesises raised.
See the contestWhat would you like to do next?
Run a Discovery
Ask a question and watch AI agents investigate it live.
OpenHonest Model Contest
Watch rival models compete — and get penalized for bluffing.
OpenExplore the Protein
Look at the real, measured 3D structure of HER2.
OpenOur one rule: nothing is dressed up as more certain than it is. Every fact you see is labeled by how we know it — measured, AI-predicted, simulation-sampled, or inferred — and models lose points for guessing.
Real Questions.
Real Science. A Brighter Future.
From individual journeys to global research, HER2T connects people and science to drive meaningful discovery.